Chemistry of Natural Products with medicinal properties
Mechanism of human blood coagulation and Fibrinolysis
Prevention of blood clots and dissolution by activation of human plasminogen
Current Activities
Dr. Doctor has recently prepared some highly active compounds from naturally sulfated polysaccharides by oversulfation, which are effective as anticoagulants and in enhancing the fibrinolytic process. These are being tested using in vitro systems under physiological conditions using purified human blood proteins such as thrombin and plasminogen. The results are evaluated by comparing these with heparin, which is a highly sulfated naturally occurring polysaccharide, widely used for treatment of cardiovascular problems.
Publications
Effect of oversulfation on the chemical and biological properties of chondroitin-4-sulfate. Y. Carranza, C. Durand-Rougley and V. Doctor. Blood Coagulation and Fibrinolysis, 18 483-487 (2008)
Effect of oversulfated chondroitin-6-sulfate or oversulfated fucoidan in the activation of glutamic plasminogen by tissue plasminogen activator: role of lysine and cyanogens bromide-fibrinogen. Y. Carranza, D. Anderson and V. Doctor. Blood Coagulation and Fibrinolysis, 19 80-85 (2008)
Vasant Doctor